• To equip this item you have to be level 60 or higher

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Progenesis is a unique Amethyst Flask that drops exclusively from Uber Maven. Its key modifier converts 25% of life loss from hits into damage over time over four seconds while the flask is active, giving builds with life recovery and leech mechanics a window to survive burst damage that would otherwise be lethal.

Lasts 4.23 to 8.78 seconds, consumes 28 to 31 of 65 charges on use, grants 35% chaos resistance, 20 to 10% reduced charges per use, 35 to 35% increased or reduced duration and converts 25% of hit-based life loss into damage over time over four seconds.

Progenesis only drops from Uber Maven and cannot be obtained through crafting or Chance Orbs. The drop rate is very low and farming Uber Maven consistently requires a build already capable of clearing one of the hardest endgame encounters in the game.

It is particularly strong for builds running Petrified Blood, life leech or recoup mechanics. It sees use across high-end mapping, bossing and deep Delve content in both softcore and hardcore.